inflammatory factors — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T64336	Izilendustat		HIF/HIF Prolyl-Hydroxylase
	Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 mins by mass spectrophotometric analysis.		HIF/HIF Prolyl-Hydroxylase
T0446	Naphazoline hydrochloride	Albalon,Rhinantin,Naphazoline HCl	Adrenergic Receptor
	Naphazoline hydrochloride (Naphazoline HCl) is an adrenergic vasoconstrictor agent used as a decongestant.		Adrenergic Receptor
T61233	Penehyclidine hydrochloride	Penequinine hydrochloride	NF-κB , AChR
	Penehyclidine hydrochloride (Penequinine hydrochloride) is an M1 and M3 antagonist and activates NF-κB in lung tissue. Penehyclidine hydrochloride inhibits the release of inflammatory factors and shows anticholinergic pr...		NF-κB , AChR
T3887	Rosarin		Others
	Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1 β, and TNF- α in the kidney and prefrontal cortex of brain in mice .		Others
T1482	Ciclopirox	HOE296b	ATPase , Ferroptosis , Antibacterial , Autophagy , Antifungal
	Ciclopirox (HOE296b) exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. Ciclopirox is a synthetic, broad-spect...
T6S1049	Wilforine		ATPase
	Wilforine is a sesquiterpene pyridine alkaloid; important bioactive compound in T. wilfordii plants, and is effective in treating idiopathic pulmonary fibrosis. Wilforine has anti-inflammatory effect, which might be medi...		ATPase
TN4234	Hydrangenol		NOS , NF-κB , Nrf2 , NO Synthase , Antifection , Autophagy
	Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can reduce MMP and inflammatory cytokine expression and increa...		NOS , NF-κB , Nrf2 , NO Synthase , Antifection , Autophagy
T9543	Syk Inhibitor II hydrochloride		Others
	The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of...		Others
T12848	SB-657510		Others , Neurotensin Receptor
	SB-657510 is a urotensin II (UII) receptor (UT) antagonist. The Ki values of UT for human, monkey, cat, rat and mouse were 61, 17, 30, 65 and 56 nM, respectively. SB-657510 plays an anti-inflammatory role by inhibiting U...		Others , Neurotensin Receptor
T1611	Isotretinoin	13-cis-Retinoic acid	Retinoid Receptor , Endogenous Metabolite , Autophagy
	Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. Isotretinoin is a naturall...		Retinoid Receptor , Endogenous Metabolite , Autophagy
T9113	Myristicin	Myristicine	IL Receptor , Anti-infection , BCL , P450 , PARP , 5-HT Receptor , Caspase , GABA Receptor , NO Synthase
	Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with ...
T3123	Allicin		ERK , IL Receptor , Others , IκB/IKK , p38 MAPK , TNF , ROS , Caspase , Antifection
	Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells. Allicin could significantly inhibit vascular smooth mus...
T63006	DHU-Se1
	DHU-Se1 is a potent anti-inflammatory agent. DHU-Se1 stimulates the release of reactive selenium compounds from macrophages and reduces the expression of cellular inflammatory factors such as iNOS and TNF-α. DHU-Se1 bloc...
TN5369	Dehydroleucodine	Dehydroleucodin
	Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating a...
T62364	CSF1R-IN-5
	CSF1R-IN-5 is a potent inhibitor of CSF1R. CSF1R-IN-5 can affect the exchange of inflammatory factors between TAM and glioma cells. CSF1R-IN-5 has the potential to be used in the study of cancer diseases.
TN3070	4beta-Hydroxywithanolide E		PARP , HSP , NF-κB , COX
	4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it...		PARP , HSP , NF-κB , COX
T72102	Glucocorticoid receptor modulator 1
	Glucocorticoid receptor modulator 1 is a potent, orally active, non-steroidal selective glucocorticoid receptor modulator, exhibiting IC50 values of 9 nM and 130 nM against NF-κB and AP-1, respectively. It effectively re...
T62342	CSF1R-IN-4
	CSF1R-IN-4 is a potent inhibitor of CSF-1R. CSF1R-IN-4 can affect the exchange of inflammatory factors between TAM and glioma cells. CSF1R-IN-4 has potential for the study of cancer diseases. EGFR-IN-40.
T78732	BO-1
	BO-1, a benzoate ester, exhibits antibacterial properties, effectively inhibiting multidrug-resistant Staphylococcus aureus. It synergizes with antibiotics like Ciprofloxacin, reversing resistance in antibiotic-resistant...
T74799	NF-κB-IN-8		NF-κB
	NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2. Additionally, it inhibits ALP activity and is usable in inflammation research, inclu...		NF-κB